Focus Workshop Slides 2012 June
Program of EBF Focus Workshop “Hatching” June 12-13, 2012
PDF renditions of the powerpoint presentations can be viewed and downloaded from this page by clicking the specific point on the program.The program itself can be viewed and downloaded by clicking here.
Day 1 – 12 June 2012
MORNING PLENARY SESSIONS
Introduction and aim of the meeting
- Philip Timmerman (on behalf of EBF)
Welcome and introduction, aim of the meeting - CT. Viswanathan (CT Viswanathan & Associates, Inc.)
Keynote: Bringing New Technologies into Regulatory Space
Special Topics and Interesting Techniques
- William van Dongen (TNO Triskelion)
iHUMITE: A cost efficient and accurate human drug metabolite profiling workflow - Martijn Hilhorst (PRA International)
Advantages and recent developments in the use of photo-spray ionisation for quantitative bioanalysis - Bruce Thompson (AB Sciex)
Pushing the limits of increased selectivity, dynamic range and sensitivity for bioanalytical applications
Alternative MS-techniques for quantitative bioanalysis
- Benno Ingelse (MSD)
Keynote: Towards High Resolution MS in Regulated Bioanalysis - Jaap Wieling (QPS)
Application of ICP-MS and LC-ICP-MS in Drug Development - Erik Baltussen (WIL)
ICPMS and tailored sample preparation for unusual bioanalyical applications - Steven Watt (A&M)
High Resolution and Accurate Mass Spectrometry for Specific and Sensitive Quantification of Target Compounds in Complex Matrices - Fabio Garofolo (Algortihm Pharma)
HR-MS in High Throughput Regulated Bioanalysis: A thorough and Practical Evaluation of Performance, Roubustness and Return on Investment - Diego Rodriguez Cabaleiro (Waters Europe)
Accurate Mass MS/MS an Attractive Option For the Quantification of Biotherapeutics in DMPK Studies
AFTERNOON PLENARY SESSIONS
Miniaturization and/or automation of sample preparation techniques?
- Kevin Bateman (MSD)
Keynote presentation: Development of Quantitative Nanoscale Techniques for Ultra Trace Analysis of Biological Microsamples - Lieve Dillen (Janssen R&D)
Blood microsampling and bioanalysis in preclinical species - Ove Jonsson (AstraZeneca)
Capillary Microsampling: “Better science – Fewer animals” - Brigitte Buscher (TNO Triskelion)
Microdialysis as a tool in drug research and development - Sheelan Ahmad (GSK)
The Application of Solid – Phase Micro-Extraction and Micro-Sampling/ a Multipurpose Micro-Technique for Bioanalysis
Tissue Analysis
- Markus Stoeckli (Novartis)
Keynote presentation: We Can See – Mass Makes the Difference - Jonathan Stauber (ImaBiotech)
Maldi imaging of small histological tissue applied to ophthalmology: qualitative and quantitative approach in drug discovery - Andrew McEven (Quotient Bioresearch)
MALDI Tissue Imaging: More than Just a Pretty Picture? - Hermann Mascher (Pharm-Analyte Labor)
Some practical aspects in tissue analysis - Nathalie Mokrzycki (MSD)
EBF Topic team on tissue analysis: plans
Day 2 – 13 June 2012
MORNING BREAKOUT SESSIONS
Focus on Large molecules: Emerging platforms in support of LBA
- John Allinson (ICON Development Solutions)
Keynote presentation: New and Automated Technology Platforms in Bioanalysis (To come) - Karen Dowers (CRL)
A Hybrid LBA-QPCR Technique (Proseek) for Improved Assay Sensitivity - Denise Sickert (Novartis)
Homogeneous immunoassay using AlphaLISA technology – the “no wash” high-throughput alternative to ELISA for PK, PD and immunogenicity measurement during drug development - Bryan Krastins (ThermoFisher Scientific)
Mass Spectrometric Immunoassays - Graig Stovold (Quotient Bioresearch)
Going round again: Lessons learnt from establishment and validation of methods on the Gyrolab Workstation (To come)
Focus on Small molecules: Miniaturization and diversification in LC-MS interfacing
- Sabeth Verpoorte (University of Groningen)
Keynote: Incorporating Multifunctionality into Microchip Separations - Marc De Meulder(Janssen R&D)
Hatching sensitivity in Bioanalysis The promise of chip based micro LC/MS - Paul Rainville (Waters Corporation)
Capillary Scale LC/MS/MS for High Sensitivity Bioanalysis Is This A Reality and Where Are The Pit Falls - Tina Settineri (Eksigent)
Micro LC/MS: Miniaturizing LC for LC/MS applications in bioanalysis
MORNING PLENARY SESSIONS
Applications and validation approaches for Emerging platforms in support of LBA
- Jenny Hendriks (Crucell)
Keynote presentation: Challenges in Development and Validation of an Intracellular Cytokine Staining assay - Carsten Lindemann (EUFETS GmbH)
Validation of a PCR for the quantification of residual plasmid DNA in samples from a biodistribution study for a therapeutic RNA vaccine - Jan Detmers (Chimera Biotec GmbH)
Case Studies on ultra-sensitive immunoanalytics based on Imperacer® (Immuno-PCR) in clinical settings. - Jason Cook (AstraZeneca)
Validation of a multiplexed cytokine panel in human serum using a Randox Evidence analyser and comparison to other platforms (Luminex and MSD) - Philip Timmerman and C.T. Viswanathan
Panel discussion connecting back on scope of FM (To come)
AFTERNOON PLENARY SESSIONS
GBC feedback
- Peter van Amsterdam (on behalf of GBC)
Feedback from GBC Harmonization team leaders Face to face (March 2012) - Philip Timmerman (Janssen R&D)
Feedback and input A2 – Tiered approaches to method validation - Ben Gordon (on behalf of Servier)
S1 – Small molecule specific run acceptance harmonization team progress report - Steve White (GSK)
S2 – Small molecule specific assay operation - Stuart McDougall (Covance)
S3 – Chromatographic run quality assessment - Chris Beaver (Pharmanet)
L1 – Large molecule specific run operation - Chris Beaver (Pharmanet)
L2 – Large molecule specific assay operation - John Smeraglia (HLS)
L3 – Assay Formats - Tom Verhaeghe (Janssen Research and Development)
A8 – Documentation
